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These systems require copper-binding motifs with more negative reduction potentials to stabilize the Cu(I) oxidation state

These observations can be translated into normal mice by augmenting their LLF glutathione thru inhibition of GGT enzyme activity ( in vivo as shown in previous human clinical trials as a cancer therapeutic ( in vivo and has been utilized in a renal ischemia/reperfusion injury model in rats ( Interestingly, systemic delivery of GGsTop at a single time inhibited serum GGT activity in a dose dependent manner and to a greater degree than airway delivery

Retrieved March 18, 2022

Based on its role in decongesting stored RBCs from accumulating oxidized proteins, and the decline in its activity during storage, its enhancement has been suggested as a promising approach to counteract storage lesion (Pandey et al., 2022)