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Description
However, to date, oligonucleotide therapeutics are still facing some technological obstacles, such as how to achieve efficient oligonucleotide delivery to target organs or tissues, how to overcome off-target interactions [4952], and how to address the sequence- and chemistry-dependent toxicity and saturation of endogenous RNA processing pathways [53, 54]
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& Rayens, W
doi: 10.1016/j.lwt.2022.114249 [DOI] [Google Scholar] Bicu A., Mattuzzi F
