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Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production

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These bacteria are able to reach the tumor core, an area that is not accessible by most drugs, to trigger several modalities of programmed cell death and to turn immunologically cold tumors into hot tumors. In summary, engineered attenuated Salmonella is an intelligent living drug platform that can self-replicate, actively target tumors, and deliver multifunctional payloads