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Illustratively, susceptible to multiple types of toxicity, corneal endothelium in patients with glaucoma may incur damage, also due to various medical and surgical interventions in addition to the disease itself [72,73]

The majority of reactive metabolites can be categorized as soft electrophiles, including quinones, quinone-imines, iminoquinone methides, epoxides, arene oxides, and nitrenium ions, which can readily react with soft nucleophiles such as the sulfhydryl group in glutathione (GSH) and cysteine residue in proteins

van Egmond M, van Garderen E, van Spriel AB, Damen CA, van Amersfoort ES, van Zandbergen G et al

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