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Supplements, unlike drugs, do not have to go through rigorous studies to prove safety and efficacy before hitting store shelves, meaning they are subject to minimal oversight, says Zeller, who worked on supplement issues at the FDA in the 1990s

Oral supplementation works because approximately 1% of an oral dose is absorbed through passive diffusion, bypassing the need for intrinsic factor

These areas (upper arms, outer-upper thighs, and belly area) have fewer blood vessels than muscle, which allows nutrients to absorb more slowly and consistently over time