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The woman underwent skin prick tests (SPT) with cyanocobalamin and hydroxocobalamin (both at a concentration of 1 mg/mL)

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Cell death was further assessed by counting nuclei and Propidium Iodide (PI) staining ( Figures 1D, E )

Estrogen-driven collagen decline accelerates during perimenopause, and substrate is typically already more depleted at baseline
