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A 2025 study published in Biogerontology demonstrated dose-dependent telomere length extension in normal human cells through upregulation of hTERT (the telomerase catalytic subunit) and telomerase enzyme activity meaning Epithalon appears to reactivate the cellular machinery that maintains telomere length rather than just slowing its shortening
[DOI] [PubMed] [Google Scholar] Kruegel AC, Gassaway MM, Kapoor A, Vradi A, Majumdar S, Filizola M, Javitch JA, Sames D (2016) Synthetic and receptor signaling explorations of the Mitragyna alkaloids: mitragynine as an atypical molecular framework for opioid receptor modulators
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