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Shen B, Yi X, Sun Y, Bi X, Du J, Zhang C, et al

Peroxisome proliferator-activated receptor gamma (PPAR) agonists inhibit Th17-cell production by eliminating GLS1, reducing the levels of the downstream metabolite of -KG, 2-HG, and downregulating the levels of the activating histone marker of H3K4 methylation (H3K4me3) in the promoter and CNS2 regions of the IL-17 gene ( Figure 2 ) (51, 52)

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Papalazarou, V
