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It would therefore be conceivable that development of ligands capable of specifically activating signalling complexes with the least capacity to trigger the regulatory mechanisms underlying tolerance could result in more prolonged analgesic actions than those of currently available opioids

This yielded to conflicting results, raising questions about whether PN could be a direct consequence of their interaction or an additional systemic feature of PD on which B12 deficiency can act as a negative predictive factor (Comi et al

In: Riederer P., Laux G., Nagatsu T., Le W., Riederer C., editors