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This pathway results altered in more than 40% of metastatic melanoma patients, including the majority of those with NRAS -mutant tumors ( MITF ) and EGFR genes have shown the highest frequency of genomic amplification, with a lower rate in primary melanomas as compared to metastatic melanomas, considering both tumor tissues and cell lines ( The diagnosis of primary melanoma is not always straightforward, especially when histologic features of the lesion overlap with those of various precursor lesions

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