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Isocitrate dehydrogenases (IDH) IDH also facilitates the generation of NADPH from NADP + by catalyzing the oxidative decarboxylation of isocitrate to -ketoglutarate (-KG) for TCA cycle

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References 1.World Health Organization Facts Sheets: Depressive Disorder (Depression) WHO

From there, it enters your bloodstream to travel to the liver
