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Of the three formulations, the conventional Neuromax B12 was the least effective in raising circulatory vitamin B12 levels, with a significant increase only on day 5 (275.5 23.8 mg/mL) ( p = 0.018) and never exceeding the borderline threshold (Figure 5 boxplots, center)

For patients with severe B12 deficiency, we may recommend an initial loading phase of daily or weekly injections to quickly restore B12 levels

Medicare and most payers require clear documentation of the dose administered, the week preceding the first dose (if applicable), and related CPT codes for injection administration