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Description
Studies demonstrate that ROS can activate pro-inflammatory factors via pathways like mitogen-activated protein kinase (MAPK) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) [90,91,92]
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After their reach to 80% confluence

It facilitates the reciprocal exchange of intracellular glutamate and extracellular cystine in a 1:1 ratio, ushering cystine entry into the cell