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22 indicates that, aided by the presence of lattice hydrogen, the Ru center in Ru-hydroxide exhibits significant electron transfer and rapid valence transitions throughout the catalytic process

Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function

Furthermore, these nanosystems prolong uricase efficacy through immunomodulation, collectively highlighting the pivotal role of nanocarriers in enhancing drug bioavailability, targeting, and multi-pathway synergistic therapy