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Uremic sarcopenia is a frequent and serious complication in CKD patients [110]

The key variables are patent expiration dates (by type), regulatory exclusivity expiration, the number and quality of Paragraph IV filers, litigation outcome probabilities, and the timing of 180-day exclusivity periods for the first generic filer

However, recent findings indicate that C/EBP negatively regulates MDSC differentiation, making it a potential therapeutic target in myeloid cells
