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Excitotoxic neuroprotection and vulnerability with CaMKII inhibition

In resistant cases, by comparison, two distinct failure modes emerge, in which either terminally exhausted T-cell clones prevail and exhibit restricted stem-like potential and epigenetic fixation into dysfunctional states that impair immediate effector function or the memory precursor pool contracts, leading to loss of long-term immune surveillance

The string glutathione peroxidase AND biotic stress AND cell death AND plant was used for this search, with the Boolean connector AND used in the string to group keywords and main terms

An open-label phase II study of F-652 showed significant improvement in MELD scores for 18 patients by day 4 [259]