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Additionally, DNA damage by oxidative stress frequently activates the SOS response pathway, which induces the UvrABC excision nuclease as well as the Rec recombinational machinery (Imlay and Linn, 1987)
A clinical trial (NCT03072992) revealed that intravenous Curcumin (CUC-1) combined with Paclitaxel significantly improved the ORR (51%) compared to placebo (33%), with an even greater effect in patients completing treatment
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Participants will be randomly assigned to receive either felzartamab or placebo for over 20 weeks
