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Most users start noticing subtle changes after 3-4 weeks of consistent use, with more significant improvements visible after 6-12 weeks

Instead, the researchers were also unsure why the gap closed after an additional four weeks of study, but offered the explanations that the different groups may not have been eating enough to get the full benefit of their training, or, conversely, had overtrained

Together, these findings further substantiate the stress-associated anxiety-like phenotype in KI mice and demonstrate that, despite repeated elevated plus maze testing, a 7-day inter-test interval is sufficient to reliably detect anxiety-like behavior