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Bone 120 , 239245 (2019)

As mitochondrial efficiency declines and oxidative stress accumulates, cells lose the resources they need to maintain DNA, regulate inflammation and repair tissue

The studies performed in subjects with chronic exposure to arsenic [27], or with clinically relevant intoxication by mercury [76], and in experimental animals intoxicated by mercury [77], cadmium and lead [78] show that the levels of some indicators of oxidative stress are displaced towards a pro-oxidative condition

Abstract The central nervous system (CNS) diseases are major contributors to death and disability worldwide
