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Today, AOD-9604 remains a topic of scientific interest, not as an approved therapy, but as a case study in how translational challenges can derail promising preclinical results

Miller JW, Smith A, Troen AM, Mason JB, Jacques PF, Selhub J

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Potential side effects include: Injection site reactions, including redness, swelling, bruising, pain, or irritation Mild fluid retention (edema) Joint or muscle discomfort Headache, dizziness, or flushing Changes in glucose regulation, particularly in individuals with diabetes or prediabetes Itching, restlessness, drowsiness, nausea, or difficulty swallowing (3) Importantly, the occurrence of potential side effects does not predict an individual's overall response to therapy