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Clade I contained isoenzymes C, B, and E, with most genes (17 of 20) expressed in roots and exhibiting high expression levels (Fig

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These mediators stimulate fibroblast proliferation and extracellular matrix deposition while promoting M2 macrophage polarization, collectively accelerating pulmonary fibrogenesis ( 2.5 Oxidative stress, ferroptosis and DNA damage RCS-adsorbed Fe 2+ catalyzes hydroxyl radical (OH) generation via Fenton reactions, triggering dysregulated intracellular redox homeostasis characterized by ROS overaccumulation ( Figure 1 )

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