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EFSA Journal 16(11): e05333 [PubMed] [PMC] Eskridge W, Cryer DR, Schattenberg JM, Gastaldelli A, Malhi H, Allen AM, Noureddin M, Sanyal AJ (2023) Metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated steatohepatitis: The patient and physician perspective

Research suggests that supplementing with 5 g of creatine monohydrate combined with 100 g of carbohydrates daily for 4 days may cause mild gastrointestinal discomfort in some individuals

Current serotonin medications are aimed at increasing central 5-HT neurotransmission in the brain, and there are no approved indications for manipulating peripheral 5-HT, though peripheral 5-HT synthesis is being considered as a potential target for developing pharmacological agents in some disorders ( We are not aware of prior studies reporting low S-5-HT in hypothyroidism or CFS

21 The patient in the scenario above also was determined to have a previously undiagnosed OTC deficiency on her post-mortem exam