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Mov Disord off J Mov Disord Soc 35:14661471 [DOI] [PMC free article] [PubMed] [Google Scholar] Comi C et al (2014) Peripheral nervous system involvement in Parkinsons disease: evidence and controversies

Patients should carefully evaluate their options while considering: Provider credentials and experience Facility accreditation Treatment protocols offered Total cost of care, including follow-up visits M1C B12 injections are specialized, combining methionine, inositol, choline, and vitamin B12, and require consideration of various cost factors, including provider selection, treatment frequency, and location-specific pricing

For example, the delineation of sub-cellular folate and one-carbon metabolism in mitochondria and the nucleus (8), the importance of formate in said metabolism (9, 10), identification of the transcobalamin receptor by which vitamin B12 is taken up into cells (11), and delineation of the sequence of events underlying intracellular vitamin B12 processing (1214)