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This is an intriguing finding given that we had observed decreases in ACE2 receptor levels in response to supplementation with LCLT in previous human study (16)

Depade), prevents the reinforcing effects of alcohol by interfering with its enhancement of the mesolimbic DA transmission [111] strengthening the potential of caffeine, and more specifically of A2 A R antagonists, for future development of preventive/therapeutic strategies for AUD

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