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References: [1] Seiwerth, S., Milavic, M., Brcic, L., & Sikiric, P

For example, to reduce immunogenicity of therapeutic mouse monoclonal antibodies, either the mouse Fc fragment or the whole antibody constant regions (CH1CH3) were replaced with the human counterparts by means of genetic manipulations, whereas the mouse Fab or Fv (VH-VL) fragments retained the original epitope specificity

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For instance, treatments with apple polysaccharides, flos lanicera, and Bofutsushosanan herbal remedy from Japanhave been successful in promoting the growth of beneficial bacteria like Lactobacillus and Bacteroidetes , improving intestinal barrier integrity, and decreasing pro-inflammatory cytokines such as TNF- and IL-6 [117,118,119]