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However, subsequent steps in the reaction require Fe 3+ and physiological temperatures to efficiently proceed and ultimately produce H 2 S, pyruvate, NH 3 , and recycle VitB 6
89 Ectopic expression of IDH2 R172K in CD4 + T cells was shown to lead to markedly increased levels of 2-HG, histone-3 lysine methylation and 5-methycytosine, and decreased 5-hydroxymethylcytosine
Michel MC, Beck-Sickinger A, Cox H, Doods HN, Herzog H, Larhammar D, Quirion R, Schwartz T, Westfall T
Zoroddu, S., Di Lorenzo, B., Paliogiannis, P., Mangoni, A
