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Low-grade neuroinflammation as indexed by heightened levels of pro-inflammatory mediators (e.g., TNF-, IL-1, and COX-2) and activation of astrocytes and microglia, main immune cells in the brain, was observed in the hippocampus and piriform cortex regions of the brain of chronic sleep-deprived rats along with neurobehavioral alterations (anxiety, learning, and memory impairments) 136

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