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Strikingly, the level of synthesis of FAHFA isomers is highly correlated to insulin sensitivity with their synthesis being dramatically reduced in adipose tissue of humans exhibiting insulin resistance
Similarly, in vitro exposure of macrophages to 10 M of ACh prior to endotoxin challenge reduces TNF- production by increasing adenylyl cyclase 6 activity, leading to cAMP formation, CREB phosphorylation, and the expression of c-Fos, a known inhibitor of TNF transcription (85)
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