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Description
IGF-1 receptors undergo ligand-induced internalization and degradation when chronically stimulated, reducing cell surface receptor density by 3050% within 34 weeks in myocyte culture models

Phan K, Sebaratnam DF (2019) JAK inhibitors for alopecia areata: a systematic review and meta-analysis

Scand J Rheumatol 1995

Mitochondrial dysfunction plays a key role in glaucoma, leading to RGC death by disrupting energy metabolism and increasing the production of ROS
