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Similarly, in healthy adults following a self-selected vitamin C-restricted diet [88] and an initial week of placebo supplementation, taking 500 mg L-ascorbate per day for weeks two and three and 2000 mg per day for weeks four and five in a six-week trial led to an increased level of glutathione in red blood cells

Issues raised in academic and consumer reviews include irritation in cosmetic-formulation use, very wide variation in product quality across the unregulated marketplace, formulation-stability problems, ingredient-interaction concerns, and a thin clinical-trial evidence base relative to the strength of consumer marketing claims

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oleifera vary widely across countries and languages, reflecting its broad geographic distribution and cultural importance [18,19]