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Specifically, women with PCOS have an increase in the expression of AGE and RAGE in the theca and granulosa cell layers, compared to healthy women [34, 64]

Even if previous data suggest the tumoricidal activity of mCRP and its potential induction in leukemia cell lines in vitro, there exists a study elucidating the critical link between CRP, integrin 2, and FcRI pathways in MCF10A breast cells and MDA-MB-231 triple-negative human breast cancer cells, thus providing useful evidence on the CRP-induced aggressiveness of breast cells in inflammatory microenvironments [156]

Chronic neuroinflammation activates the transcription factor C/EBP, which in turn up-regulates the cysteine protease asparagine endopeptidase (AEP) (85)

The CPT1C 5 UTR contains a repressing upstream open reading frame that is regulated by cellular energy availability and AMPK