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Microglia mediated neuroinflammation in parkinson's disease

doi: 10.1152/physrev.1983.63.2.547

Subsequent studies from other groups have confirmed our original findings.65 Pleiotropic effects involving distinctive receptors, including VEGFR2 and growth hormone receptors, distinctive pathways, including VEGFR2-AKT-eNOS, ERK , FAK-paxillin, FoxO3a, p-AKT, p-mTOR and p-GSK-3, and distinctive loops, including stimulation of the egr-1 gene and its corepressor gene naB2, and counteraction of increases in pro-inflammatory and procachectic cytokines, likely minimize the inherent lack of full understanding of the mechanisms that may be involved

The SSP pathway sustains immunosuppressive M2 macrophage activation and TAM expansion in tumor-bearing mice 137