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Throughout the 1990s and 2000s, the Orange Book expanded its listings and refined its therapeutic equivalence codes, providing clearer guidance on drug substitutability.[1] The Orange Book Goes Online The transition to an online format in 2005 marked a major advancement, making the Orange Book more accessible and allowing for real-time updates.[2] Today, it remains an indispensable tool for healthcare providers, pharmacists, drug manufacturers, and legal professionals, playing a pivotal role in ensuring the availability of safe and effective generic drugs, promoting competition in the pharmaceutical market, and supporting informed decision-making in healthcare

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A series of alkanoates of 3-methyl-3-sulfanylbutan-1-ol ((CH 3 ) 2 C(SH)CH 2 CH 2 OC(O)R) and a series of alkanoates of 3-sulfanylhexan-1-ol (CH 3 CH 2 CH 2 CH(SH)CH 2 CH 2 OC(O)R) have been detected in the fruit peel of Poncirus trifoliata (a close relative of citrus) (Starkenmann et al., 2007)

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