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Higher DNA methylation means that there will be lower expression of the NOS3 enzyme and lower endothelial nitric oxide

Bae, K.-R., Shim, H.-J., Balu, D., Kim, S
When redox homeostasis is disturbed (e.g., genetic mutations, environmental toxins, or therapeutic side effects), oxidative stress develops

Cardiac copper concentration gradually decreases after ischemic injury and is positively correlated with HIF-1-mediated expression of angiogenic and glycolytic genes [48]
