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The solution was first precipitated using methanol (AR, 99.5%, Shanghai Titan Scientific Co., Ltd.)-dichloromethane (AR, 99.5%, Shanghai Titan Scientific Co., Ltd.) with a volume ratio of 1:10:25 to obtain dark green powder with the removal of formamide

Moreover, NAD+ is also a key player in redox reactions, and its depletion is thought to contribute to the development of oxidative stress

Adult male dopamine -hydroxylase knockout (DBH / ) mice and controls (DBH +/+ or DBH +/ ) at 9- to 12-months of age were treated with ICV PBS (DBH WT Control, N = 3), no surgery (DBH KO Controls, N = 5), or 10 ng/hr leptin (both DBH WT, N = 5 and DBH KO, N = 2)