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Quick Answer: Adding glutathione to the Myers' Cocktail creates a synergistic antioxidant cascade: vitamin C in the Myers' formula directly regenerates oxidised glutathione back to its active form

Although this competitive phenomenon has not yet been observed in the brain, it may be a significant reason for the poor efficacy and side effects of many therapeutic approaches, warranting further investigation

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Although we have shown a strong association between upstream p38 MAPK inhibition and downstream Nrf2 activation coupled with functional improvementand this regulatory relationship is consistent with established mechanismsdirect experimental confirmation of Nrf2s necessity in this pathway, such as through the use of Nrf2-specific inhibitors or genetic knockout approaches, will be required in future work