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Funding This work is not supported by any funding national or international agency

Supporting this, PET imaging studies revealed species-dependent differences in BBB P-gp/ABCB1 function, with significantly greater increases in (R)-[11C]verapamil brain distribution observed in rats compared to humans at equivalent plasma levels of tariquidar [167]

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The change in optical density was measured after 15 min at 412 nm spectrophotometrically (Sunrise Tecan)
