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Studies have focused on its ability to reduce inflammation and improve insulin sensitivity

In: Caplan LR, Siesjo BK, Weir B, Welch KM, Reis DJ (eds)
Tilg et al
How does Dihexa cross the blood-brain barrier more effectively than other peptides? Dihexa achieves 0.87% injected dose per gram brain tissue in pharmacokinetic models nearly 10-fold higher than typical peptide-based neuroactive compounds, which average less than 0.1% brain uptake due to size exclusion at endothelial tight junctions