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Co-authored by Lauren Baker, DVM, PhD This article was co-authored by Lauren Baker, DVM, PhD

Important Considerations for Combining NAD+ and AOD9604 Despite the theoretical appeal, several crucial points must be considered when exploring the combination of NAD+ and AOD9604: Lack of Direct Combined Research: The most significant caveat is the current lack of extensive human clinical trials specifically investigating the combined effects of NAD+ precursors and AOD9604

The study, Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial, was published in the journal JAMA Neurology

Mood changes, including depression or irritability, can also be related to low B12 levels