melanotic macule/nevus Melanocytic nevi and malignant melanoma Benign Pigmented Skin Lesions |
Description
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Trials typically incorporate biomarker endpoints such as ER/ER ratios, aromatase activity, plasma isoflavone or polyphenol concentrations, immune cell phenotyping, cytokine panels, oxidative stress markers and microbiome profile which are used to provide mechanistic read-outs of supplement activity and to inform patient stratification approaches (231)
Examination of the mucous membrane of the hard palate revealed several blue-pigmented macules with ill-defined borders merging into the surrounding mucosa (Figure 2)
