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The characteristic dermatological sign of vitamin B 12 deficiency is cutaneous pigmentation, which can be reversed by administration of vitamin B 12 .[4] Increased cutaneous pigmentation is especially accentuated in palmar creases, on the dorsa of hands and feet, in intertriginous areas, on oral mucosa and in recent scars

The Guidelines are not intended as a substitute for the advice or professional judgment of a health care professional, nor are they intended to be the only approach to the management of clinical problem

These findings collectively demonstrate that FOXO4-DRI alleviates OGD-induced endothelial cell senescence and restores functional damage caused by OGD