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Effects of IGF-1 in pathophysiological conditions It is extensively documented that IGF-1 exerts profound effects on CV and metabolic disorders
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NAMPT overexpression can extend cell proliferation capabilities and enhance stress resistance through SIRT1-mediated p53 degradation 212
Understanding the IGF-1 system in neurons, including the regulation of IGF-1 availability and signaling mechanisms, could be an important aspect for development of ALS therapeutic approaches 14
