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Description
UV radiation is considered one of the most important inducers of cutaneous melanoma (223, 224)
The incidence of dementia among DS patients is 10% in the age range 3550 yr and 55% in the age range 5060 yr and becomes 75% above the age of 60 yr, but AD neuropathology is present in virtually all adults with DS older than 40 yr (460)
doi: 10.1155/2017/6274854
Subsequently, nuclear Nrf2 binds to small Maf proteins increasing the transcription of ARE-driven genes, which encode for phase II detoxification enzymes
