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Over time, the constant excretion of cortisol begins to fatigue the adrenal glands, and because the adrenals produce reserve stores of sex hormones, such as estrogen, progesterone, and testosterone, it may cause the body to steal the materials needed to make these sex hormones and convert them into more cortisol

The physiological mechanisms of the pathway is not fully known but research studies are pointing to the loss of the more stable negative feedback loop of regulatory function in favor of the less stable and ultimately destructive positive feedback loop response as a possible etiology

Encouraging hydration and gentle alkalinity (mineral water, leafy greens) to aid copper clearance

This article is based on publicly available scientific literature and user reported experiences