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Whether mitochondria, which are classically implicated in programmed cell death pathways (19), are affected by glutathione reductase inhibition is unknown

ROS are a necessary defense system to combat microbial respiratory infections (Lambeth, 2004), but oxidative stress and the excessive production of ROS by numerous cells including monocytes and macrophages, neutrophils, as well as pulmonary endothelial and epithelial cells play a major role in the development of ARDS and its complications during COVID-19 infections (Meftahi et al., 2021)

H., & Shih, C

An error at any step cascades through the rest