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PCG1- binds to various transcription factors and nuclear receptors that recognize specific sequences in their target genes and promotes the mitochondrial biogenesis and oxidative phosphorylation in cancer cells and also promotes tumor metastasis (133) and drug resistance in colorectal cancer cells by regulating endoplasmic reticulum stress (134)

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For example, combining TGF- inhibitors with drugs that modulate macrophage polarization could be particularly effective

Among them, Cyanocobalamin, SC-58125, Dexamethasone, and Rofecoxib are well-studied PD drugs, suggesting the reliability of our method in identifying drugs for PD