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Even though they have limitations (low bioavailability, high metabolism, poor water solubility), these molecules have antitumorigenic effects against a wide range of cancers: colon, lung, prostate, breast, gastric, liver, and brain cancer ( Bioactive compounds target cancer cells, macrophages and adipocytes in the tumor microenvironment, thereby preventing cancer development and progression ( Tripterygium wilfordii used in the Chinese medicine contains bioactive compounds such as triptolide, celastrol and tripchlorolide that also inhibit PI3K/Akt and NF-B pathways thereby exerting anticancer and anti-inflammatory effects ( As previously mentioned, several plant-derived bioactive compounds are effective in improving male infertility

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2022YFB3203800, 2017YFC1309100 and 2017YFA0205200), National Natural Science Foundation of China (Nos

Hence, it is imperative to assess the efficacy of complementary and alternative medicine as a safe adjunct treatment that may reduce inflammation and alleviate symptoms