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In order to be successfully synthesized in ER, the chaperone GRP78 is induced and activated to promote the refolding process of misfolded proteins (Yoboue et al., 2017) , (Wei et al., 2012)
In addition, studies on two other multicationic analogs with a similar triphenylamine core structure as TPCI, indicated that increasing the number of cationic branches could enhance the binding affinity of the AIEgens to DNA
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