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Description
Carotenoids in marine animals

once daily for 6 days and after 4 days once 50.0 mg/kg b.w., i.p.) or reserpine (a catecholamine vesicles depletor) (5.0 mg/kg b.w., i.p.) were applied

The primary outcome of both studies was the change from baseline to week 78 in Clinical Dementia Rating Sum of Boxes (CDR-SB) scores

Phenformin was well tolerated up to high concentrations, which agrees with its previous use as an antidiabetic drug before it was withdrawn from the market in the 1970s due to more frequent fatal cases of lactic acidosis compared to the alternative antidiabetic metformin