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Quantitatively, the lesion diameter caused by Ltgpx3 mutants without DPI treatment was found to be only 54% of the diameter observed with DPI treatment
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Uncoupling protein 1 (UCP1) is similarly regulated by glutathionylation for thermogenesis, but the smaller need for immediate regulation prompts Grx1 and Trx2 to perform UCP1 reduction, albeit at a much lower efficiency [45]
